BENRALIZUMAB (Fasenra) prior authorization at Priority Health
Submission criteria, P2P prep, and appeal path if denied — for prescribers and PA staff
Priority Health requires Interleukin-5 Receptor alpha-directed Cytolytic Antibody prior-authorization documentation for BENRALIZUMAB (Fasenra): a diagnosis with ICD-10 code, documented step-therapy history, and prescriber attestation of medical necessity. Standard PA decisions return in 30 days; if denied, prescribers and members have 180 days to appeal.
The PA criteria you'll need to meet
Priority Health reviews BENRALIZUMAB (Fasenra) prior authorizations against its medical policy for Interleukin-5 Receptor alpha-directed Cytolytic Antibody. Priority Health-specific context: Subsidiary of Corewell Health (Michigan integrated health system, formed from Beaumont + Spectrum 2022); ~1.3M members. Second-largest insurer in Michigan after BCBS Michigan. Michigan DIFS oversight.
Documentation packet checklist
- Chart note with diagnosis (ICD-10 code) and clinical severity markers
- Documented failure of, contraindication to, or intolerance of step-therapy alternatives in Interleukin-5 Receptor alpha-directed Cytolytic Antibody
- Prior treatment history including dosing, duration, and reason for discontinuation
- Relevant labs, imaging, or assessment scores supporting medical necessity
- Prescriber attestation linking the FDA-approved indication to the patient's presentation
- Priority Health's medical policy URL referenced in the cover letter
Priority Health's common denial patterns
Pre-empting these patterns in the initial submission cuts rework and shortens time-to-approval:
- West Michigan narrow-network restrictions
- Step therapy on specialty drugs
- Medicare Advantage Part B drug step therapy
- Behavioral health network adequacy
BENRALIZUMAB (Fasenra)-specific denial patterns and context
Across payers (not just Priority Health), BENRALIZUMAB (Fasenra)draws a distinct set of denial reasons rooted in the drug's label, REMS, and competitive landscape:
- Eosinophil count threshold (≥300 cells/µL within 12 months)
- Step therapy requiring mepolizumab first within IL-5 class
- Indication restriction (severe asthma vs EGPA — December 2024)
Brand: Fasenra. IL-5 receptor α monoclonal antibody. Approved for severe eosinophilic asthma; expanded to eosinophilic granulomatosis with polyangiitis (EGPA) September 2024.
Manufacturer patient-assistance program: Benra360 Patient Support — relevant when a Priority Health denial sticks and the patient needs bridge access while appealing.
How Priority Health approaches Biologic drugs (mAbs and biosimilars) PAs
Priority Health's Biologic drugs (mAbs and biosimilars) reviewer typically anchors BENRALIZUMAB (FASENRA) prior-auth decisions on step therapy on specialty drugs and medicare advantage part b drug step therapy. Pharmacy-benefit review for BENRALIZUMAB (FASENRA) at Priority Health is routed through Express Scripts. The 30-day standard review window starts when the prior-authorization request is received with all required documentation — incomplete packets pause the clock and add 5-10 days to time-to-approval, after which the 180-day internal-appeal window begins from the denial date. Priority Health's utilization-management vendor (Carelon, eviCore, OptumRx, or in-house) sets the step-therapy ladder — appeals that cite ACR, AAD, or AGA guideline language directly to the medical director shorten escalation. Priority Health is domiciled in MI, so unresolved appeals escalate to the MI insurance department's external-review program for fully-insured policies (self-funded ERISA plans route to the DOL EBSA instead). Subsidiary of Corewell Health (Michigan integrated health system, formed from Beaumont + Spectrum 2022); ~1.
If the PA is denied
Priority Health gives prescribers and members 180 days to file an internal appeal. Standard appeal decisions return within 30 days. Submit through the provider portal (https://www.priorityhealth.com/provider) with the same packet plus a peer-reviewed citation supporting BENRALIZUMAB (Fasenra)for the patient's indication.
Helping a patient appeal the denial directly? See the consumer guide: How to appeal a Priority Health denial on DenialHelp.
Contact Priority Health
- Provider portal: https://www.priorityhealth.com/provider
Frequently asked questions
What documentation does Priority Health need for BENRALIZUMAB (Fasenra) prior auth?
Priority Health's typical PA packet for BENRALIZUMAB (Fasenra): (1) chart note documenting the indication and prior-treatment failures, (2) supporting lab/imaging where indicated, (3) prescriber attestation that step-therapy alternatives were tried or contraindicated, (4) FDA-approved indication mapped to ICD-10 diagnosis. For Interleukin-5 Receptor alpha-directed Cytolytic Antibody, expect clinical-criteria documentation specific to this class.
What's the turnaround time at Priority Health?
Standard BENRALIZUMAB (Fasenra) PA decisions at Priority Health: 30 days. Urgent / expedited (member's life or function at risk): 72 hours under 45 CFR §147.136.
What does Priority Health most often reject BENRALIZUMAB (Fasenra) for?
Across Priority Health's book the common rejection patterns include: West Michigan narrow-network restrictions; Step therapy on specialty drugs; Medicare Advantage Part B drug step therapy. For BENRALIZUMAB (Fasenra) specifically, expect step-therapy challenges and indication-restriction reviews when the use is at the edge of the FDA label or off-label.
What prior failures does Priority Health typically require before approving BENRALIZUMAB (FASENRA)?
Priority Health's biologics step-therapy ladder for most indications begins with a conventional DMARD (methotrexate, sulfasalazine, leflunomide) or topical/inhaled first-line, then a step-1 biologic (typically a TNF inhibitor or adalimumab biosimilar), then the requested agent. Document trial duration (≥12 weeks for most biologics), dosing reached, and reason for discontinuation (inadequate response by disease-activity score, intolerance, or contraindication). For BENRALIZUMAB (FASENRA), attach the specific disease-activity instrument Priority Health accepts (e.g., DAS28, PASI 75, HBI, Mayo) — appeals with raw symptom narrative but no scored instrument carry higher denial rates. Pharmacy-benefit handling is routed through Express Scripts. External-review escalation for Priority Health fully-insured policies sits with the MI insurance department.
How do I prep for a peer-to-peer with Priority Health on BENRALIZUMAB (Fasenra)?
Lead with the FDA-approved indication and the specific clinical criteria the policy lists. Have the patient's chart open, document number, and policy URL on screen. State your name and credentials, the policy number, the indication, and the documented failures of step-therapy alternatives. Keep notes — if the P2P reviewer overturns, get the decision in writing.
Related PA criteria
Generate the BENRALIZUMAB (Fasenra) PA packet
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